 Oxygen and Wound healing “Availability of oxygen (Po2) to the local wound area is essential for the wound healing processes”
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- Whitney JD, Acute Surgical And Traumatic Wound In Bryant RA, Nix DP, Acute & Chronic Wounds –Current Management Concepts, ed 3,
St. Louis, 193 Mosby 2007 |
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Oxygen as a infection control agent
“Oxygen is the key to phagocytosis and killing of bacteria by neutrophils or Polymorphonuclear cells (PMNs)”
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- Babior BM, Oxygen-dependant microbial killing by phagocytes, New England Journal of Medicine 198:659, 1978 |
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Oxygen and Growth factors
“Topically applied oxygen alters angiogenesis-related growth factor expression in wound fluids from chronic diabetic foot ulcers in a manner consistent with revascularization and renewed healing.”
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- Scott GF, Reeves RE, Topical Oxygen Alters Angiogenesis-related Growth Factor Expression in Chronic Diabetic Foot Ulcers. Presented at: New Cardiovascular Horizons; Fort Worth, Texas. Oct 01, 2005 |
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Oxygen stimulates angiogenesis
“Angiogenesis is a critical early aspect of the wound healing response. Supplemental Oxygen administration accelerates vessel growth."
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- Knighton D et al, Regulation of wound healing and angiogenesis – effect of oxygen gradients and inspired oxygen concentrations. Surgery 90:262-270 1981 |
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Collagen synthesis is dependent on Oxygen
“Rapid and optimal re-epithelialization depends on sufficient oxygenation.”
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- Pai MP, Hunt TK. Effect of varying oxygen tension on healing in open wounds. Surg Gynecol Obstet; 135756-757 1972 |
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The Advantages of EpiFLO® Transdermal Sustained Oxygen Therapy
“The advantages of topical oxygen therapy include low cost, lack of systemic oxygen toxicity, and the ability to receive treatment at home, making the benefits of oxygen therapy available to a much larger population of patients.”
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- Kalliainen LK, Topical oxygen as an adjunct to wound healing: a clinical case series. Pathophysiology. Jan; 9(2):81-87. 2003 |
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Oxygen Deficit and Pain
“It is important to recognize that oxygen drives chronic pain pathways primarily by its absence.”
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- Ali M “The oxygen view of pain: every chronic pain represents cells' cries for oxygen". Townsend Letter for Doctors and Patients. Jan 2005 |
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Said, H.K. et al. Transdermal Sustained-delivery oxygen improves epithelial healing in a rabbit ear wound model Arch Surg, 2005, October 140(10): 998-1004 |
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Hypoxia delays Wound healing 
"Correcting hypoxemia through the administration of supplemental oxygen (O2) can have a significant beneficial impact on wound healing in a perioperative and outpatient settings."
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- G.M. Gordillo, C.K. Sen Revisiting the essential role of oxygen in wound healing The American Journal of Surgery 186 (2003) 259-263 |
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Oxygen and Antibiotic killing of bacteria 
“Oxygen can be seen as having a strong antibiotic effect on wound healing”
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- Wilson C et al, Amputation Date Cancelled Due to the Use of Transdermal, Sustained Oxygen Therapy in the Healing of a Diabetic Foot Ulcer with Osteomyelitis. Poster presented at American Professional Wound Care Association Philadelphia PA April 1 2005 |
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| Converg Medical will be at the ( this is in the conferences section) WUWHS – World Union of Wound Healing Societies – Toronto Conference Centre Toronto ON June 4-8 2008 drop by and see us at corner booth 2122 www.wuwhs.org |
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| Converging caring with cost savings |
Converg Medical Corporation is dedicated to providing patients, clinicians and homecare health providers with leading edge technology products that improve clinical outcomes while decreasing healing times and healthcare costs.
EpiFLO® is a proven breakthrough therapy restoring regenerative wound healing capacity impaired by disease, trauma or other factors. |
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